Training projects for master and bachelor students
We welcome master and bachelor students to join our lab for semester projects, internship, and theses. Students who like to join as a lab member and conduct a relatively long-term project will be considered with preference. Interested candidates should email Prof. Tang (email@example.com) their CVs containing completed courses, GPA, and research experience (if any), and schedule a meeting with Prof. Tang or a mentor to discuss their potential research interest and time commitment for conducting research in Tang lab.
There are several training projects available for semester projects, summer internship, or master theses depending on the time commitment of the student:
Nanogel synthesis and interaction with immune cells
The goal of this project is to synthesize biomacromolecule nanogels with responsive linkers and study their interaction with immune cells. The students will investigate how to control the composition, size, and surface properties of nanogels, and characterize the chemical and physical properties of the nanomaterials. They will next explore the interaction of various nanogels with T-cells, B-cells, dendritic cells, and macrophages and the dependence of their chemo-physical properties.
Chemical syntheses of responsive linkers and nanovaccines
The goal of this project is to design, conduct, and scale up the organic syntheses of small molecule responsive linkers and prepare nanovaccines. The students will learn the basic organic syntheses techniques and use NMR, MS, and HPLC to characterize the molecules. They will next prepare vaccines by linking antigens and adjuvant molecules using the synthesized linkers and study how the nanovaccines interact with antigen presenting cells.
Selective antibody modification and engineering
The goal of this project is to develop novel bioconjugation techniques to selectively modify antibodies. The students will investigate how to control the binding and dissociation of antibodies by varying chemical, physical or biological conditions, and learn how to modify antibodies through bioconjugation with polymers and responsive linkers. They will then study and characterize the binding specificity of the modified antibodies and their responsive activation.
Chemotaxis of immune cells
The goal of this project is to investigate the chemotaxis of immune cells, in particular, T cells, macrophages, and dendritic cells. The students will use transwell, cell monolayer, or tissue sections to establish reliable assays to study the chemotaxis behavior of immunes cells induced by single or combination of chemokines.