Journal Articles (Peer-Reviewed)

Google Scholar profile;   ORCID ID

*: corresponding author; #: equal contribution


Guo, Y.; Tang, L.* “A Magnetic Nanovaccine Enhances Cancer Immunotherapy”, ACS Cent. Sci. 2019, Article ASAP, DOI: 10.1021/acscentsci.9b00325.


Xie, Y-Q.; Arik, H.; Wei, L.; Zheng, Y.; Suh, H.; Irvine, D.J.; Tang, L.* “Redox-Responsive Interleukin-2 Nanogel Specifically and Safely Promotes the Proliferation and Memory Precursor Differentiation of Tumor-Reactive T-Cells”, Biomater. Sci. 2019, 7, 1345-1357. Invited contribution as Biomaterials Science Emerging Investigator.


Lei, K.; Tang, L.* “Surgery-free injectable macroscale biomaterials for local cancer immunotherapy”, Biomater. Sci. 2019, 7, 733-749. Invited review.


Zhao, Y.; Guo, Y.; Tang, L.* “Engineering Cancer Vaccines Using Stimuli-Responsive Biomaterials”, Nano Res. 2018, 11, 5355–5371. Invited review.

Special issue: 2018 Nano Research Young Innovators (NR45) Award in nanobiotechnology


Tang, L.*; Zheng, Y.; Melo, M.B.; Mabardi, L.; Castaño, A.P.; Xie, Y.-Q.; Li, N.; Kudchodkar, S.B.; Wong, H.C.; Jeng, E.K.; Maus, M.V. and Irvine, D.J. “Enhancing T-cell Therapy Through TCR Signaling-Responsive Nanoparticle Drug Delivery”, Nat. Biotech. 2018, 36, 707-716.

Cover story of Nature Biotechnology, Volume 36 Issue 8, August 2018. 

News & Views “A backpack revs up T-cell activity” in Nat. Biotech.

Highlighted: MIT News, EPFL News, EurekAlert!,, Nanowerk, My Science, eCancer, Health Canal, Medindia, Madrid,, Science and Enterprise, Brinkwire, Sina, BioArt


Guo, Y.; Lei, K.; Tang, L.* “Neoantigen Vaccine Delivery for Personalized Anticancer Immunotherapy”, Front. Immunol. 2018, 9, 1499. Invited review.


Yin, Q.; Tang, L.; Cai, K.; Yang, X.; Yin, L.; Zhang, Y.; Dobrucki, L.W.; Helferich, W.G.; Fan, T.M. and Cheng, J. “Albumin as a “Trojan Horse” for polymeric nanoconjugate transendothelial transport across tumor vasculatures for improved cancer targeting”, Biomater. Sci. 2018, 6, 1189-1200


Xie, Y-Q.; Wei, L.; Tang, L.* “Immunoengineering with Biomaterials for Enhanced Cancer Immunotherapy”, WIREs Nanomed. Nanobiotechnol. 2018, 10, e1506. Invited review.


Zheng, Y.; Tang, L.; Sudha Kumari, S.; and Irvine, D.J. “Enhancing Adoptive Cell Therapy of Cancer through Targeted Delivery of Small-Molecule Immunomodulators to Internalizing or Noninternalizing Receptors”, ACS Nano 2017, 11, 3089-3100.


Yang, Y.S.; Atukorale, P.; Moynihan, K.; Bekdemir, A.; Rakhra, K.; Tang, L.; Stellacci, F. and Irvine, D.J. “High-Throughput Quantitation of Inorganic Nanoparticle Biodistribution at the Single-Cell Level Using Mass Cytometry”, Nat. Comm. 2017, 8, 14069.


Wang, H.; Wang, R.; Cai, K.; He, H.; Liu, Y.; Yen, J.; Wang, Z.; Xu, M.; Sun, Y.; Zhou, X.; Yin, Q.; Tang, L.; Dobrucki, I.T.; Dobrucki, L.W.; Chaney, E.J.; Boppart, S.A.; Fan, T.M.; Lezmi, S.; Chen, X.; Yin, L.; Cheng, J. “Selective in vivo Metabolic Cell-Labeling-Mediated Cancer Targeting”, Nat. Chem. Biol. 2017, 13, 415-424.


Yin, Q.#; Tang, L.#; Tong, R.; Sternberg, R.; Yang, X.; Dobrucki, L.W.; Borst, L.B.; Kamstock, D.A.; Cai, K.; Song, Z.; Helferich, W.G.; Cheng, J. and Fan T.M. “Pamidronate Functionalized Nanoconjugates for Targeted Therapy of Focal Skeletal Malignant Osteolysis”, Proc. Natl. Acad. Sci. 2016, 113, E4601-4609.

Highlighted: NIH Director’ Blog, FierceBiotech, Noodles, EurekAlert!,, Nanotechnology Now, Drug Discovery & Development, Bioscience technology, Azonano, Science Daily, Laboratory Journal,, Nanowerk, Engineering at Illinois.


Wang, H.; Tang, L.; Liu, Y.; Dobrucka, I.T.; Dobrucki, L.W.; Yin, L. and Cheng, J. “In Vivo Targeting of Metabolically Labeled Cancers with Ultra-Small Silica Nanoconjugates”, Theranostics 2016, 6, 1467-1476.


Azzi, J., Yin, Q., Uehara, M., Ohori, S., Tang, L., Cai, K., Ichimura, T., McGrath, M., Maarouf, O., Kefaloyianni, E., Loughhead, S., Petr, J., Sun, Q., Kwon, M., Tullius, S., von Andrian, U.H., Cheng, J. and Abdi, R. “Targeted Delivery of Immunomodulators to Lymph Nodes”, Cell Reports 2016, 15, 1202-1213.

Prior to EPFL


Tang, L.; Coyle, V.J.; Tong, R.; Yin, Q.; Pondenis, H.; Shor, S.; Borst, L.; Cheng, J.; Fan T.M. “Targeting Tumor Vasculature with Aptamer Functionalized Doxorubicin-Polylactide Nanoconjugates for Enhanced Cancer Therapy”, ACS Nano 2015, 9, 5072-5081.


Hotaling, N.A.#; Tang, L.#; Irvine, D.J.; Babensee, J.E. “Biomaterial Strategies for Immunomodulation”, Annu. Rev. Biomed. Eng. 2015, 17, 317-349.


Tang, L.#; Yin, Q.#; Xu, Y.; Zhou, Q.; Cai, K.; Yen, J.; Dobrucki, L.W. and Cheng, J. “Bioorthogonal Oxime Ligation Mediated In Vivo Cancer Targeting”, Chem. Sci., 2015, 6, 2182-2186. 


Tang, L.; Yang, X.; Yin, Q.; Cai, K.; Wang, H.; Chaudhury, I.; Yao, C.; Zhou, Q.; Kwon, M.; Hartman, J.A.; Dobrucki, L.W.; Dobrucki, I.T.; Borst, L.B.; Lezmi, S.; Helferich, W.G.; Ferguson, A.L.; Fan, T.M. and Cheng, J. “Investigating the Optimal Size of Anticancer Nanomedicine”, Proc. Natl. Acad. Sci. 2014, 111, 15344-15349.

Highlighted: Engineering at Illinois, Nanowerk, MedicalXpress, Science Daily, Nanotechnology Now, Daily News, EurekAlert!, Azonano, Health Canal, Bionity, Controlled Environments, Technology Org., Nature Science-Business eXchange 7(43); doi:10.1038/scibx.2014.1275.


Tong, R.; Tang, L.; Ma, L.; Tu, C.; Baumgartner, R. and Cheng, J. “Smart Chemistry in Polymeric Nanomedicines”, Chem. Soc. Rev. 2014, 43, 6982-7012.


Tang, L.; Cheng, J. “Nonporous Silica Nanoparticles for Nanomedicine Applications”, Nano Today 2013, 8, 290-312.


Tang, L.; Gabrielson, N.P.; Uckun, F. M.; Fan, T.M. and Cheng, J. “Size-Dependent Tumor Penetration and In Vivo Efficacy of Monodisperse Drug-silica Nanoconjugates”, Mol. Pharm. 2013, 10, 883-892.


Xing, H.#; Tang, L.#; Yang, X.#; Hwang, K.; Wang, W.; Yin, Q.; Dobrucki, W.L.; Yasui, N.; Katzenellenbogen, J.A.; Helferich, W.G.; Cheng, J. and Lu, Y. “Enhanced Breast Cancer Therapy with Nucleolin-Aptamer-Functionalized Liposomes”, J. Mater. Chem. B 2013, 1, 5288-5297.


Wang, H.; Tang, L.; Tu, C.; Song, Z.; Yin, Q.; Yin, L.; Zhang, Z.; Cheng, J. “Redox-Responsive, Core-Cross-Linked Micelles Capable of On-Demand, Concurrent Drug Release and Structure Disassembly”, Biomacromolecules 2013, 14, 3706-3712.


Zhang, Y.; Yin, Q.; Yin, L.; Ma, L.; Tang, L.; Cheng, J. “Chain-Shattering Polymeric Therapeutics with On-Demand Drug-Release Capability”, Angew. Chem. Int. Ed. 2013, 52, 6435-6439.


Tang, L.; Yang, X.; Dobrucki, W.L.; Chaudhury, I.; Yin, Q.; Yao, C.; Lezmi, S.; Helferich, W.G.; Fan, T.M. and Cheng, J. “Aptamer-Functionalized, Ultra-Small, Monodisperse Silica Nanoconjugates for Targeted Dual-Modal Imaging of Lymph Nodes with Metastatic Tumors”, Angew. Chem. Int. Ed. 2012, 51, 12721-12726.

Highlighted: Nature Science-Business eXchange 5(45); doi:10.1038/scibx.2012.1193.


Tang, L.; Fan, T.M.; Borst, L.B. and Cheng, J. “Synthesis and Biological Response of Size-Specific, Monodisperse Drug-Silica Nanoconjugates”, ACS Nano 2012, 6, 3954-3966.


Tang, L.; Azzi, J.; Kwon, M.; Mounayar, M.; Tong, R.; Yin, Q.; Moore, R.; Skartsis, N.; Fan, T.M.; Abdi, R.; Cheng, J. “Immunosuppressive Activity of Size-Controlled PEG-PLGA Nanoparticles Containing Encapsulated Cyclosporine A”, J. Transplant. 2012, Article ID 896141.


Cely, I.; Yiv, S.; Yin, Q.; Shahidzadeh, A.; Tang, L.; Cheng, J.; Uckun, F.M. “Targeting Mantle Cell Lymphoma with Anti-SYK Nanoparticles”, J. Analy. Oncol. 2012, 1, 1-9.


Chen, K.J.#; Tang, L.#; Garcia, M.A.; Wang, H.; Lu, H.; Lin, W.Y.; Hou, S.; Yin., Q.; Shen, C.K.F.; Cheng, J.; Tseng, H.R. “The Therapeutic Efficacy of Camptothecin-Encapsulated Supramolecular Nanoparticles”, Biomaterials 2011, 33, 1162-1169.


Mishra, A.; Lai, G.H.; Schmidt, N.W.; Sun, V.Z.; Rodriguez, A.R., Tong, R.; Tang, L.; Cheng, J.; Deming, T.J.; Kamei, D.T.; Wong, G.C.L. “Translocation of HIV TAT Peptide and Analogues Induced by Multiplexed Membrane and Cytoskeletal Interactions”, Proc. Natl. Acad. Sci. 2011, 108, 16883-16888.


Azzi, J.#; Tang, L.#; Moore, R.; Tong, R.; El, Haddad N.; Akiyoshi, T.; Mfarrej, B.; Yang, S.; Jurewicz, M.; Ichimura, T.; Lindeman, N.; Cheng, J.; Abdi, R. “Polylactide-Cyclosporin A Nanoparticles for Targeted Immunosuppression”, FASEB J. 2010, 24, 3927-3938.


Chaney, E. J.; Tang, L.; Tong, R.; Rezaeipoor, R.; Cheng, J.; Boppart, S. “Lymphatic Biodistribution of Polylactide Nanoparticles”, Mol. Imag. 2010, 9, 153-162.


Tong, R.; Coyle, V.J; Tang, L.; Barger, A.M., Fan, T.M.; Cheng, J. “Polylactide Nanoparticles Containing Stably-Incorporated Cyanine Dyes for In Vitro and In Vivo Imaging Applications”, Microsc. Res. Tech. 2010, 73, 901-909.


Tong, R.; Christian, D.A.; Tang, L.; Cabral, H.; Baker, J.R. Jr.; Kataoka, K.; Discher, D.; Cheng, J. “Nanopolymeric Therapeutics”, MRS Bulletin 2009, 34, 422-431.


Lu, C.; Qi, L.; Yang J.; Tang, L., Zhang, D.; Ma, J. “Hydrothermal Growth of Large-scale Micropatterned Arrays of Ultralong ZnO Nanowires and Nanobelts on Zinc Substrate”, Chem. Commun. 2006, 3551-3553.



Irvine, D.J.; Zheng, Y.; Tang, L. “Efficient and Stable Cell Surface Coupling of Nanoparticles”, U.S. provisional patent application, 2015.


Tang, L. ; Irvine, D.J. “Carrier-Free Biologically-Active Protein Nanogels”, US Patent 20150110740, 2015. Licensed.


Cheng, J; Tang, L. “Silica Nanoparticle Agent Conjugates”, US 61/418,230 2010, WO PCT/US2011/062548, 2011 (TF09149).