The overarching goal of Tang laboratory is to establish the detailed understanding of the interactions between synthetic biomaterials and the immune system so that we can precisely modulate the immune response using engineered intelligent biomaterials for effective and safe immunotherapies for cancer, infectious diseases, and autoimmune disorders. We leverage the power of state-of-the-art synthetic chemistry, materials science and nanotechnology to advance the diagnosis and therapy of human diseases. The ultimate goal is to translate new materials and technologies for clinical applications. There are three major components in our research program: 1) design and syntheses of novel organic or inorganic biocompatible biomaterials with highly controlled properties for immunoengineering; 2) study of the interdependent interactions between synthetic biomaterials/nanomedicines and the biological system, in particular, the immune system; 3) control of the biophysicochemical properties of biomaterials to precisely modulate the immune responses to treat cancer and other diseases.
I. Tumor-microenvironment-specific immuno-modulation for enhanced and safe cancer immunotherapy
II. Responsive nanovaccine against cancer neoantigens